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Peptide therapy is considered scientifically a fighter against the most common aging signs, the enhancing tool of the body's energy. That is based on the use of different peptides like:
Peptide therapy targets to supply the body with the essential materials that aim to heal the human body
By shedding the light more on the peptides, we will find that peptides are short chains of amino acids.
Generally, amino acids are the building blocks of protein and these amino acids are created to target specific functions within the human body. The body uses peptides as the ones that transport instructions to specific cells. That can lead to an increase in the rate at which certain actions can happen at a cellular level. These processes can lead to an overall increase in speed at the levels of healing, rejuvenation, and growth. As peptides bind themselves to targeted receptors at the level of the membrane of related cells and function only happens when a signal is sent to the receptor to activate. The peptide is then delivered to the parts of the human body that is in need to be repaired and the healing process happens to overall the area.
Peptides have the ability to utilize body chemistry connections to enhance restoration, anabolism, and homeostasis
Boosting energy
Peptides have the advantage of being able to send hormones directly into the bloodstream. As an example; Ipamorelin can enhance memory retention, increase the rate of metabolism, and work on pain relieving. By having this peptide, the pituitary gland is stimulated to give more of it naturally.
Weight loss
It had been found that peptides have the ability to aim at real weight loss based on lipolysis, or the breakdown of fatty cells, besides enhancing metabolic functions and muscle building
As an example, there are two peptides that are called; CJC1295,AOD 9604
CJC1295 is a synthetic peptide that has the ability to boost protein synthesis, which leads to enhancing metabolic function
AOD 9604 is a peptide that controls eliminating obesity to a great extent, as it burns fat by stimulating the pituitary gland and regulating the metabolic rate. It has a great ability to even inhibit the formation of fat in the human body.
CJC 1295 is a synthetic form that carries aesthetic advantages including enhanced skin quality and tightness and a decrease in frown lines, crow’s feet, hair regrowth, under-eye wrinkles, and other signs of aging. It has antioxidative stress activity.
It had been found also based on clinical studies, and scientific research that peptides contribute to enhancing sexual life
For men they help to improve erectile function as well as increase libido. In women, it contributes to improving desire, and satisfaction.
Generally, based on scientific realities, peptide therapy is the future of regenerative medicine that will benefit to our health.
5-amino-1MQ is a small molecule drug that functions to block the activity of an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT plays a significant role in metabolism and energy and is predominantly active in fat tissue.
By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1).
SIRT1 is also known as ‘the longevity gene’ because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.
This means that 5-amino-1MQ allows your body to burn fat for energy while maintaining muscle mass preferentially. 5-amino-1MQ is both safe and effective for reversing and preventing diet-induced obesity.
It is a potentially superior treatment option for individuals suffering from (or who are at risk for) type II diabetes and other metabolic comorbidities to obesity. Furthermore, the activation of SIRT1 by an increase in NAD+ suggests 5-amino-1MQ is a good option for patients who are looking to develop a comprehensive anti-aging protocol.
AOD-9604 is a synthetic analog of the human growth hormone developed to combat obesity and help people trying to lose weight. AOD-9604 stimulates the pituitary gland similar to HGH and other growth hormones to speed up the metabolism and increase weight loss in a shorter period of time than just diet and exercise alone.
ARA 290 is an 11-amino acid linear peptide and an innate repair receptor (IRR) agonist. The IRR is a heteromer of the erythropoietin receptor and the beta-common (CD131) receptor, which simultaneously activates anti-inflammatory and tissue repair pathways.Experimental data suggest that after peripheral nerve injury, the IRR is unregulated in the spinal cord and modulates the neurogenic inflammatory response.
Neuropathic pain is observed in a large variety of disorders that vary from metabolic and infectious disorders, which affect the small, afferent sensory nerve fibers such as sarcoidosis to diseases of the central nervous system like multiple sclerosis.
In this study, ARA290 displayed efficacy in preclinical models of disease, including neuropathy, without associated adverse effects. In the models from this study, this peptide has been shown to reprogram a proin-flammatory, tissue-damaging milieu into one of healing and repair.
PC 157 is available as a subcutaneous injection and as an oral capsule.
Cerebrolysin is a low molecular weight, porcine-derived peptide preparation with free amino acids that has a variety of clinical applications due to its neuroprotective and neurotrophic properties. Cerebrolysin has pharmacodynamic neurotrophic and neuroprotective activity that mimics endogenous neurotrophic factors. Neurotrophic factors are molecules that are responsible for growing, maintaining and repairing neurons.
Cerebrolysin is a combination of peptides including Nerve Growth Factor, Brain-Derived Neurotrophic Factor, Ciliary Neurotrophic Factor, Enkephalins, and Orexin.
This peptide is extremely safe and well tolerated. No major side effects have been reported. Standard injection site redness is the only known
Although the method of action that Cerebrolysin uses to promote neuroregenic and neuroprotective activity are not completely understood, it is believed it interacts with inhibitory modulators.
CJC-1295 is an incredibly effective growth hormone and works by causing another substance to be secreted. It stimulates the release of your own body’s growth hormone which. Research shows that after the age of 30 the body’s growth hormone level drops quickly and approximately 15% every 10 years. CJC-1295 is able to increase growth hormone naturally by binding to receptors for growth hormone releasing hormone (GHRH) on your brain and more specifically the pituitary gland. By doing this it triggers the brain to release growth hormone that would have otherwise been lost with age.
CJC 1295 should not be used while pregnant or breastfeeding. Always tell your physician about all medications and supplements, especially corticosteroids and thyroid medications, that you are taking. Common side effects of CJC 1295 include reactions at the injection site, such as pain, redness or swelling along with flushing of the face; and less than 1 percent of patients report dizziness, headache or hyperactivity.
Dihexa is a nootropic (cognitive enhancer) and a small peptide that has been developed by researchers from Washington State University to potently improve certain cognitive function of potential trauma-based brain disorders and neurodegenerative conditions through increased synaptogenesis.
Dihexa has also been called a “neurogenic wonder-drug” and the peptide can be ten million times stronger than BDNF (Brain-derived neurotrophic factor), one of the leading medications for new synapse formation.
If you’re someone looking to enhance your mental stamina and improve your memory overall, Dihexa may be your solution to dramatically improving cognitive function.
The DSIP or the Delta sleep-inducing Peptide is a somnogeneric peptide that impacts neuromodulation. It is typically found in the brain and passes by the blood barriers quite quickly. Studies have shown that DSIP and as well as its analogs are classified as peptide neuromodulators.
Studies have also shown that DSIP has exhibited a stress-protective action that helps decrease stress metabolic disorders for humans and animals. It is believed that the Delta Sleep-Inducing Peptide works in such a way that it modulates the activity of GABAergic gluta and other neuronal systems too.
It is not recommended to give out DSIP just before going to bed. The dose should be given during the day to help improve sleep the next night and as well as several days to come.
Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin, which is naturally produced in the pineal gland.
Epitalon’s primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA so the body can grow new cells and rejuvenate old ones.
Younger people produce a relatively large amount of telomerase and longer telomeres. The longer the telomere strands are, the better cell health and replication they provide. However, as people age, the production of telomerase falls and consequently cell replication and health decline. This is one reason that people age. Epithalon also plays a role in regulating metabolism, increasing the sensitivity of hypothalamus to its natural hormonal influences, normalizing the function of the anterior pituitary and regulating the levels of gonadotropins and melatonin in the body.
Epitalon offers a number of benefits that can help combat the symptoms of aging. It also helps with mood, and acts as an antioxidant.
Numerous studies have shown the importance of telomerase production and telomere rejuvenation in fighting the symptoms of aging. As Epitalon has been shown to increase the production of telomerase which in turn strengthens and lengthens telomeres, this means that Epitalon can play a vital role in decreasing the aging process and thus extend human longevity.
Ipamorelin acts in a completely different way to stimulate growth hormone release. Ipamorelin helps to release growth hormone because it mimics ghrelin. Ghrelin is one of three hormones which together act to regulate growth hormone release from the pituitary gland. This is an important distinction between both peptides because Ghrelin also works at the pituitary gland and is responsible for initiating the breakdown of fat for use as energy as well as preventing the breakdown of muscles.
Ipamorelin should not be used while pregnant or breastfeeding. Always tell your physician about all medications and supplements, especially corticosteroids and thyroid medications, that you are taking. Common side effects of Ipamorelin include reactions at the injection site, such as pain, redness or swelling along with flushing of the face; and less than 1 percent of patients report dizziness, headache or hyperactivity.
Bremelanotide PT-141 was developed from the peptide hormone Melanotan II for aphrodisiac effects. Bremelanotide PT-141 effects sexual function via interaction with the hypothalamus. Its usage has been found to induce rapid onset of arousal. Found to increase erection in 80% of males who did not respond to Viagra or Cialis. Bremelanotide PT-141 has shown to increase chances of women achieving at least one sexually gratifying experience by 50%.
Bremelanotide PT-141 is available for subcutaneous injection and intranasal spray.
Based on the literature, PT-141, has been shown to:
Unlike other sexual-enhancement drugs, Bremelanotide PT-141 acts at the level of the brain, thus eliciting rather natural sexual response.
Melatonin II (MT II) is a peptide hormone that acts to increase sexual arousal by interacting with the hypothalamus in the brain. As a derivative of MT II, Bremelanotide PT-141 induces sexual arousal by binding to melanocortin receptors in the hypothalamus
Reported side effects of Bremelanotide PT-141 are flushing, nausea and gastrointestinal upset No contraindications have been reported.
Honokiol is a poly-phenolic compound that exerts neuroprotective properties through a variety of mechanisms. It has therapeutic potential in anxiety, pain, cerebrovascular injury, epilepsy, and cognitive disorders including Alzheimer’s disease. It has been traditionally used in medical practices throughout much of Southeast Asia, but become more widely studied due to its pleiotropic effects.
DHA-B, dihydrohonokiol-B, is a natural supplement which has anxiolytic-effects. Treatment with DHH-B does not cause any significant changes in motor activity or muscle relaxation. Benzodiazepines are some of the most commonly prescribed medications in the United States. These anxiolytics have many well-known side effects including motor function and more. That being said, this product has the potential to help people transition from benzodiazepines to DHH-B or act as an alternative to benzodiazepines.
DHH-B comes in 7.5mg capsules. Take 1-2 capsules as needed, effects diminish atter 3-4 hours
DHH-B has been shown to reduce the feeling of stress and anxiety when taken.
Alcohol should be avoided when using this supplement. This supplement may provoke sleep when alertness is required
Mechano-growth factor (MGF) is an anabolic peptide found in muscle, bone, tendon, neural, and cardiac tissue following periods of increased stress. It is a split variant or isoform of insulin -like growth factor-1 (IGF-1), also known as IGF-1Ec. MGF functions to increase stem cell proliferation in given tissues, allowing for more rapid recovery.
The hypothalamus releases GHRH and stimulates the pituitary glands production of Growth Hormone (GH). As an analog of GHRH, Tesamorelin with “Trehalose” is able to stimulate the production of GH by the same mechanism. GH goes on to stimulate IGF-1 production in the liver. The resulting increased levels of GH and IGF-1 in the blood results in a variety of beneficial growth effects in tissues.
Based on the literature, Tesamorelin has been shown to:
Tesamorelin should not be used while pregnant or breastfeeding. Always tell your physician about all medications and supplements, especially corticosteroids and thyroid medications, that you are taking. Common side effects of Tesamorelin include reactions at the injection site, such as pain, redness or swelling. Some Patient might experience joint pain, pain in legs and arms, swelling in your legs and muscle pain.
Popularly known as Ligandrol, LGD-4033 is one of the most in-demand performance enhancing substances in the market these days. Essentially, it is a newly developed selective androgen receptor modulator that largely magnetizes bodybuilders on the lookout to increase muscle mass.
LGD 4033 was made to serve a therapeutic purpose as it recreates the performance of the anabolic hormone, testosterone. This involves addressing the deterioration of the muscles and bones caused by medical conditions like muscle wasting and osteoporosis. But since the supplement has the tendency to grow mass and build bones, it became very popular.
Ligandrol has a unique mechanism of action bearing no similarities with anabolic steroids. Thereby, its effects are comparatively mild and safer on the health of its users. Similar to every SARM, it attaches and activates androgen receptors found in the bones and muscle tissues. Androgens are hormones that have a major contribution in the sexual development of males. And so, its effects favor athletes and mass gainers just as the effects of testosterone.
As LGD-4033 connects to the androgen receptors, it multiplies the efficiency of anabolic activities. This in turn, triggers the growth process of muscles, intensifies strength, and fortifies your bones.
LL-37 is an antimicrobial peptide. It has been shown to have antimicrobial activity against multiple Gram-positive and Gram-negative human pathogens. Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotics. It’s simple, AMPs kill the microbial pathogens (the bugs).
AMPs can possibly regulate bacteria/virus invasion and may control infection. It has been reported that AMPs could be used to activate the innate mucosal immune response in order to get rid of the infections. (Mucosal refers to the immune response at mucosal membranes of the intestines, the urogenital tract and the respiratory system, i.e., surfaces that are in contact with the external environment).
Several studies show that LL-37 is effective in treating certain cancer cell types. LL-37 inhibits gastric cancer cell proliferation by the activation of bone morphogenetic protein (BMP) signaling. However, overexpression of LL-37 was found to promote development and progression of ovarian, lung and breast cancers
Melanotan II (MT2) is a stimulating peptide which induces skin tanning. Melanocyte Stimulating Hormones (MSH) are a class of peptide hormones produced in the intermediate lobe of the pituitary gland that stimulate pigment cells (melanocytes) in the skin and hair to produce and release melanin which leads to darker skin and hair. Melanotan II increases melanin production via stimulation of skin pigment cells called melanocytes.
Melanin is the pigment that is responsible for our beautiful variety of skin tones and shades, eye colors, and hair colors. Not only does melanin provide pigmentation for human skin, hair, and eyes, it also provides protection against the harmful effects of ultraviolet (UV) rays.
Low levels of melanin mean that the skin is highly susceptible to DNA damage with excess sun exposure. This lack of melanin and its protection against UV radiation means that those individuals with fair skin have a propensity to burn and risk more DNA damage. It also means that a lot of time is invested in their ability to develop a tan safely without burning.
Receiving an adequate supply of vitamin D from the sun without being at risk of developing melanoma is somewhat of a balancing act. Studies have already discovered that staying out of the sun to prevent melanoma can cause vitamin D deficiency.
GHK is a tripeptide with the amino acid sequence glycyl-histidyl-lysine. It naturally occurs in human plasma, saliva, and urine. In plasma the level of GHK is about 200 ng/mL at age 20, but declines to 80 ng/mL by age 60. This decline in the GHK-level coincides with the noticeable decrease in regenerative capacity of an organism. Scientific research has shown that Scientific research has revealed that GHK can assist in wound healing, infection control, hair growth, cancer, cognitive health, and facial cosmetic use.
According to the research, GHK is a potential treatment for a variety of disease conditions associated with aging. The molecule is very safe and no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies.
GHK with and without copper affects a large number of genes related to an organism’s response to stress and injury (tissue remodeling, anti-oxidant, anti-inflammatory, anti-pain, anti-anxiety, blood vessel growth, nerve outgrowth, anti-cancer action). GHK sequence is included in the collagen molecule, and SPARC protein and GHK is naturally released after an injury due to protein breakdown.
Copper is a transitional metal that is vital for all eukaryotic organisms from microbes to humans. Since it can be converted from oxidized Cu(II) to reduced Cu(I) form, it functions as an essential cofactor in a multitude of biochemical reactions involving electron transfer.
A dozen enzymes use changes in copper oxidation states to catalyze important biochemical reactions, including cellular respiration, antioxidant defense, detoxification, blood clotting, and the connective tissue formation. Copper is required for iron metabolism, oxygenation, neurotransmission, embryonic development and many other essential biological processes
Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester, a synthetic nootropic molecule.Noopept has a similar effect to piracetam, in that it provides a mild cognitive boost after supplementation. Noopept also provides a subtle psychostimulatory effect. Noopept is also known as N-phenylacetyl-L-prolylglycine ethyl ester, Noopeptide, Ноопепт, GVS-111.
Oxytocin is well known as the ‘love hormone’ because of how it increases with touch and stimulation. This powerful hormone plays a huge role in relationships and how we partner with others. Exogenous administration of oxytocin can improve libido, organism intensity/frequency and overall sexual pleasure for both males and females.
Anti-cancer peptide, PNC-27, is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells. The peptide induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis (cell death).
PNC-27 has shown to be highly effective in selectively targeting a wide variety of specific forms of cancer, including pancreatic cancer, breast cancer, leukemia, melanoma, and additional cancer lines.
Cancer cells have HDM-2 in their cell membranes. When the PNC-27 is administered, it immediately travels to the HDM-2 located in the membranes of cancerous cells. By binding to them it creates pores or holes in the cell membrane causing death of the cell membrane. This, in turn, leads to the destruction of the cancer cell.
When cells are damaged, they sense their damage, and they can pause. This process is called cellular senescence or cellular arrest. Cells are programmed to do this because they don’t want to replicate with damage.
Instead, they pause until the immune system can clear them. Until cleared, senescent cells secrete signals that cause harm to the body. These signals increase inflammation, exhaust stem cells, and cause the body to age more rapidly. While senescence is natural, clearing senescent cells is vital to stop the aging process.
Both Selank and Semax are melanocortins and have pleiotropic effects involved in brain health and function. Selank by itself has traditionally been prescribed for anxiety and depression. Selank has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and anti-stress medication. Semax is used as a therapeutic for patients with pathologies related to brain circulation dysfunction. As a combination, Selank/Semax has applications in improving learning processes, exploratory behavior, regeneration and development, nociceptive and in ammatory processes, accelerate nerve regeneration and improve neuromuscular performance and overall neural health.
Selank and Semax act as Melanocortin Stimulating Hormone-like Peptides within the brain to initiate wide ranging e ects related to brain activity and fitness.
Selank is often prescribed for its anxiolytic properties, immune improvement, gastric protection, and with opioid and alcohol withdrawal/ dependence. Semax has been prescribed for anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal and even chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s.
The Selank/Semax combination works for patients that are interested in improving mental clarity, memory, and focus and has applications in alleviating anxiety and depression. In combination with appropriate medically supervised rehabilitation this medication has shown therapeutic agency with individuals suffering from PTSD and/or substance dependence withdrawal. This medication should not be used by pregnant or nursing patients and individuals under the age of 18.
Tesofensine is a serotonin-noradrenaline- dopamine reuptake inhibitor, which is being developed for the treatment of obesity. Tesofensine was originally being investigated for the treatment of Parkinson’s disease and Alzheimer’s disease. However, significant weight loss was consistently reported as an adverse event in the original studies. For this reason, it was decided to pursue development ofTesofensine as a treatment for obesity.
Tesofensine, primarily, acts as an appetite suppressant and could increase resting energy expenditure. Phase II trials for the treatment of obesity with Tesofensine have been completed. On average, its 6 month weight loss results from a phase 2b clinical trial resulted in a weight loss of around 25 pds.
Tesofensine is given in 500mcg oral capsules. Take one capsule by mouth once daily in the morning.
Patients that are having difficulty maintaining a healthy weight or struggling with obesity. Tesofensine offers a safe weight loss option without the cardiac risks or serious side effects associated with other drugs promoting weight loss.
This medication should not be used with any other reuptake inhibitors or SSRls. The most commonly reported side effects in the obese population are: dry mouth, headache, nausea, diarrhea, and constipation.
Thymosin Alpha-1 is a major component of Thymosin Fraction 5 found in the thymus. The thymus is responsible for regulating the immune system. Thymosin Alpha-1 is prescribed to optimize the performance of your immune health and improve general wellness by preventing infections such as the common cold or the flu. It acts to augment T-cell function; T-cells are a part of the adaptive immune system which fights off infection.
T-cells come in two forms: killer and helper cells. Killer T-cells are responsible for hunting down and destroying our body’s own cells that are cancerous or infected with bacteria or viruses. TA1 is thought to modulate the immune system by augmenting T-cell function. TA1 may affect thymocytes by stimulating their differentiation or by converting them to active T-cells.
Thymosin Alpha-1 has been shown to:
Thymosin Alpha-1 appears to be well tolerated. No adverse drug interaction has been observed. No side effects, other than some irritation or burning sensation at the site of injection, have been reported.
Thymosin is a hormone secreted from the thymus. The thymus is responsible for regulating the immune system and tissue repair. Thymosin Beta-4 has been found to play an important role in protection, regeneration, and remodeling of injured or damaged tissue. It is prescribed for acute injury, surgical repair, and patients that were once athletes that accumulated injury over their lifetime. It acts as a major actin-sequestering molecule and can be taken after cardiac injury for better healing of the tissue in the heart. It is best prescribed to be taken once daily for 20 days.
Thymosin Beta-4 is typically found in both types of muscle in the human body – skeletal (the muscles that are required to move) and smooth (muscles such as those in the heart). When damage to tissue occurs, Thymosin Beta-4 is upregulated. Thymosin Beta-4 is released in the body to help people heal from traumas. In the process of healing from injury. It also acts to reduce the amount of scar tissue and improve flexibility. It also has potent anti-inflammatory properties.
Thymosin Beta-4 has been shown to:
Thymosin Beta-4 appears to be quite well tolerated. No adverse drug interaction has been observed. No side effects, other than some irritation or burning sensation at the site of injection, have been reported.
PE-22-28 is an effective treatment for depression and a potent stimulator of neurogenesis and synaptogenesis in the hippocampus. It has far fewer side effects than existing antidepressant medications. It appears to retain much of its ability to antagonize TREK-1 even after modifications that boost half-life or alter the route of administration.
In short, PE-22-28 thus provides a strong target for guiding the development of a new generation of antidepressants and is helping to shed light on the burgeoning field of nootropics. It is also helping to expand the arsenal of medications used to treat neurodegenerative diseases like Alzheimer’s disease.
SS-31 is a class of cell-permeable small peptides, which selectively resides on the inner mitochondrial membrane and possesses intrinsic mitochondrial protective capacities. Specifically, SS-31 (also known as MTP-131) is a water-soluble mitochondria-targeting peptide that attenuates mitochondrial reactive oxygen species production and cytochrome c release. This peptide has been shown to reverse decline in diabetes, attenuate transverse aortic constriction-induced pulmonary arterial hypertension and heart failure, and rapidly rejuvenates oxidative phosphorylation in aged mice.
SS-31 is a novel mitochondrial-target therapy peptide that crosses the blood brain barrier (BBB) and targets the inner mitochondrial membrane (IMM). Mitochondria play a vital role in cellular metabolism. Because of their widespread effects on cellular functions, mitochondrial dysfunction is implicated in a wide range of diseases. Mitochondrial dysfunction results in less ATP production and insufficient energy to maintain cell function, which is followed by cell injury and even cell death.
Mitochondrial disease can greatly impact one’s health by negatively affecting almost any part of the body. Health concerns with mitochondrial disease include fatigue, diabetes mellitus, impairment of hearing and vision, weakness, metabolic strokes, seizures, cardiomyopathy, arrhythmias, developmental or cognitive disabilities, liver, gastrointestinal disorders, liver and kidney disease, and more. Many of these conditions can lead to secondary mitochondrial dysfunction and affect other diseases, including Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes and cancer.
There are no reported side effects of SS-31.
Approved in March 2022 by the FDA as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus, Tirzepatide Injection is a glucose- dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist.
In comparative head-to-head trials, Tirzepatide surpassed the HbA1c reduction of Semaglutide by an additional 24%. According to data from Phase III trial results in patients with type 2 diabetes, Tirzepatide was non-inferior and superior to Semaglutide with respect to the mean change in HbA1c from baseline to 40 weeks. In comparative head-to-head trials, Tirzepatide surpassed the HbA1c reduction of Semaglutide by an additional 24%. According to data from Phase III trial results in patients with type 2 diabetes, Tirzepatide was non-inferior and superior to Semaglutide with respect to the mean change in HbA1c from baseline to 40 weeks.
At all doses, Tirzepatide (5mg, 10mg, 15mg) also outperformed Semaglutide (1mg) in body weight reduction after 40-weeks. At 5mg, up to 80% of users achieved at least a 5% (15lb) reduction in body weight; at 10mg, 45% reached a 10% (201b) reduction; and at 15mg, up to 36% of users achieved at least a 15% (25lb) reduction in body weight compared to 54%, 24%, and 8% of Semaglutide users, respectively.
Weight decrease from baseline after 40-weeks reveals that Tirzepatide (Smg, 10mg, 15mg) offers at least 30%, 60%, and up to 95% more weight loss, respectively, vs. Semaglutide 1mg
As a GIP and GLP-1 receptor agonist, Tirzepatide is a 39 As a GIP and GLP-1 receptor agonist, Tirzepatide is a 39 amino- acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1. At therapeutic doses, it acts on center in the brain and suppress appetite. Use in conjunction with diet and exercise, Tirzepatide helps patients adhere to reduced-calorie diet, enhancing the weight loss process.
- Injectable Tirzepatide can be administered with or without food
- If you need to change the day week, ensure the previous dose was given 3 or more days before.
The most common side effects may include nausea, diarrhea, vomiting, constipation, stomach pain, headache, fatigue, dizziness, bloating, gas, and heartburn.
More serious side effects may include:
This peptide is a naturally occurring protein in humans that plays important roles in hormone signaling during puberty and reproduction. It is also thought to alter mood and behavior, promote angiogenesis, and regulate kidney function. Kisspeptin-10 has also been found in the brain and is known to suppress tumor growth and spread. It is also known and heavily studied for its ability to influence gonadotropin releasing hormone (GnRH).
Gonadotropin releasing hormone is produced and secreted by specialized nerve cells in the hypothalamus of the brain. It is released into tiny blood vessels that carry this hormone from the brain to the pituitary gland, where it stimulates the production of two more hormones – follicle stimulating hormone and luteinising hormone. These hormones are released into the general circulation and act on the testes and ovaries to initiate and maintain their reproductive functions.
KPV is the C-terminal peptide fragment of alpha-melanocyte stimulating hormone (alpha-MSH). It is a potent anti- inflammatory peptide that has shown promise in a number of disease conditions. The most active research is in the treatment of inflammatory bowel disease where the peptide has shown substantial promise. Research in wound healing also reveals that KPV may offer a host of benefits that speed wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. KPV has also been shown to aid in scar reduction after surgery.
KPV exhibits minimal side effects. It has also been shown in animal studies to be safe and effective when administered orally.
The opioid growth factor (OGF, also known as met-enkephalin)-OGF receptor (OGFr) axis works in animal and human cancer cell lines and tumors. Met-Enkephalin is a synthetic form of the naturally occurring, endogenous opioid peptide, metenkephalin, and agonist of the zeta- and delta-opioid receptor and, to a lesser extent the mu- opioid receptor.
Met-Enkephalin mimics its endogenous ligand and targets, binds to and activates the opioid receptors. This leads to an analgesic effect, inhibits neuropathic pain, and inhibits GI muscle contractility. Binding to the opioid growth factor receptor (OGFR; zeta-opioid receptor), enhances tissue growth and regeneration. In addition, activation of delta- opioid receptors located on a variety of immune cells may modulate the inflammatory immune response. This may inhibit the secretion of pro-inflammatory cytokines and the proliferation of leukocytes.
MK-677 (also known as ibutamoren), promotes the secretion of the growth hormone (GH) and increases insulin- like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain.
MK-677 (also known as ibutamoren), promotes the secretion of the growth hormone (GH) and increases insulin- like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain.
Therefore, we can expect that ibutamoren may also affect these functions. It increases growth hormone levels with little or no increase in other hormones, such as cortisol. Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.
MK 677 has not produced very many side effects for its users to be concerned about, but certain populations may have some side effects to individual who are vulnerable to insulin sensitivity or who have Diabetes may be at risk when taking MK-677.
MK 677 has not produced very many side effects for its users to be concerned about, but certain populations may have some side effects to individual who are vulnerable to insulin sensitivity or who have Diabetes may be at risk when taking MK-677.
MOTS-c is a mitochondrial-derived peptide that is primarily used for fat loss but has also shown efficacy for muscle building, improved physical performance, and as an anti-aging peptide by reversing cellular senescence*. Interestingly, the long-lived Japanese people (population with the most extended lifespan in the world) have demonstrated the phenotypic expression and biological link between MOTS-c and an extended lifespan.
MOTS-c functions to activate the mitochondrial genome, thereby increasing mitochondrial biogenesis. This process all happens through the inhibition of the methionine-folate cycle, resulting in purine synthesis and increased PCG-1 alpha and AICAR, all of which play vital roles in energy metabolism via AMP-activated protein kinase (AMPK). By stimulating AMPK, *cellular senescence is, in part, reversed.
When cells are damaged, they sense their damage, and they can pause. This process is called cellular senescence or cellular arrest. Cells are programmed to do this because they don’t want to replicate with damage.
Instead, they pause until the immune system can clear them. Until cleared, senescent cells secrete signals that cause harm to the body. These signals increase inflammation, exhaust stem cells, and cause the body to age more rapidly. While senescence is natural, clearing senescent cells is vital to stop the aging process.
NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. At the molecular level, it is a ribo-nucleotide, which is a basic structural unit of the nucleic acid RNA. Structurally, the molecule is composed of a nicotinamide group, a ribose and a phosphate group. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.
NAD+ is an essential coenzyme required for life and cellular functions. Enzymes are catalysts that make biochemical reactions possible. Coenzymes are ‘helper’ molecules that enzymes need in order to function.
NAD+ is the most abundant molecule in the body besides water, and without it, an organism would die. NAD+ is used by many proteins throughout the body, such as the sirtuins, which repair damaged DNA. It is also important for mitochondria, which are the powerhouses of the cell and generate the chemical energy that our bodies use.
